Home Transmembrane Transporters Potassium Channel inhibitor Quinine For research use only.

Quinine

Quinine, an alkaloid derived from the bark of the cinchona tree, is an anti-malaria agent and a potassium channel inhibitor that inhibits mSlo3 (KCa 5.1) channel currents evoked by voltage pulses to +100 mV with IC50 of 169 μM.

Quinine Chemical Structure

Quinine Chemical Structure

CAS No. 130-95-0

Purity & Quality Control

Batch: S449501 DMSO]65 mg/mL]false]Ethanol]65 mg/mL]false]Water]Insoluble]false Purity: 99.95%
99.95

Quinine Related Products

Signaling Pathway

Potassium Channel Signaling Pathways

Potassium Channel Signaling Pathway

Biological Activity

Description Quinine, an alkaloid derived from the bark of the cinchona tree, is an anti-malaria agent and a potassium channel inhibitor that inhibits mSlo3 (KCa 5.1) channel currents evoked by voltage pulses to +100 mV with IC50 of 169 μM.
Targets
Potassium channel [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04873011 Unknown status
Obesity
Universitaire Ziekenhuizen KU Leuven
 October 29 2020 Phase 1
NCT02817919 Completed
Malaria
African Collaborating Centre for Pharmacovigilance|Kintampo Health Research Centre Ghana|University of Health and Allied Sciences
 May 2016 --
NCT02598713 Recruiting
Pneumonia|Aspiration
Massachusetts General Hospital
 December 2015 Phase 1

Chemical Information & Solubility

Molecular Weight 324.42 Formula

C20H24N2O2
CAS No. 130-95-0 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 65 mg/mL ( (200.35 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 65 mg/mL

Water : Insoluble


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In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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